Combined treatment of pancreatic cancer xenograft with (90)Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor

AIM: To investigate the therapeutic effect of combined integrin α(6)β(4)-targeted radioimmunotherapy (RIT) and PI3K/mTOR inhibitor BEZ235 in a pancreatic cancer model. METHODS: Phosphorylation of Akt, mTOR, the downstream effectors eukaryotic initiation factor 4E binding protein 1 (4EBP1) and S6 rib...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Aung, Winn, Tsuji, Atsushi B, Sudo, Hitomi, Sugyo, Aya, Ukai, Yoshinori, Kouda, Katsushi, Kurosawa, Yoshikazu, Furukawa, Takako, Saga, Tsuneo, Higashi, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698248/
https://ncbi.nlm.nih.gov/pubmed/29204055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i42.7551
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