Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine. However, low editing efficiency has hampered the applications of CRISPR–Cas9 technology in creating knockin (KI) or knockout (KO) iPSC lines, which is...

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Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Li, Xiao-Lan, Li, Guo-Hua, Fu, Juan, Fu, Ya-Wen, Zhang, Lu, Chen, Wanqiu, Arakaki, Cameron, Zhang, Jian-Ping, Wen, Wei, Zhao, Mei, Chen, Weisheng V, Botimer, Gary D, Baylink, David, Aranda, Leslie, Choi, Hannah, Bechar, Rachel, Talbot, Prue, Sun, Chang-Kai, Cheng, Tao, Zhang, Xiao-Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212847/
https://ncbi.nlm.nih.gov/pubmed/30239926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky804
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