Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage

BACKGROUND: Precise genome editing via homology-directed repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functional genomic research and holds promise for gene therapy. However, HDR efficiency remains low in some cell types, including some of great research and clinical interest,...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Zhang, Jian-Ping, Li, Xiao-Lan, Li, Guo-Hua, Chen, Wanqiu, Arakaki, Cameron, Botimer, Gary D., Baylink, David, Zhang, Lu, Wen, Wei, Fu, Ya-Wen, Xu, Jing, Chun, Noah, Yuan, Weiping, Cheng, Tao, Zhang, Xiao-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319046/
https://ncbi.nlm.nih.gov/pubmed/28219395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1164-8
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