Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage

BACKGROUND: Precise genome editing via homology-directed repair (HDR) after double-stranded DNA (dsDNA) cleavage facilitates functional genomic research and holds promise for gene therapy. However, HDR efficiency remains low in some cell types, including some of great research and clinical interest,...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Zhang, Jian-Ping, Li, Xiao-Lan, Li, Guo-Hua, Chen, Wanqiu, Arakaki, Cameron, Botimer, Gary D., Baylink, David, Zhang, Lu, Wen, Wei, Fu, Ya-Wen, Xu, Jing, Chun, Noah, Yuan, Weiping, Cheng, Tao, Zhang, Xiao-Bing
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319046/
https://ncbi.nlm.nih.gov/pubmed/28219395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1164-8
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