Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression

Genome editing of human induced pluripotent stem cells (iPSCs) is instrumental for functional genomics, disease modeling, and regenerative medicine. However, low editing efficiency has hampered the applications of CRISPR–Cas9 technology in creating knockin (KI) or knockout (KO) iPSC lines, which is...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Li, Xiao-Lan, Li, Guo-Hua, Fu, Juan, Fu, Ya-Wen, Zhang, Lu, Chen, Wanqiu, Arakaki, Cameron, Zhang, Jian-Ping, Wen, Wei, Zhao, Mei, Chen, Weisheng V, Botimer, Gary D, Baylink, David, Aranda, Leslie, Choi, Hannah, Bechar, Rachel, Talbot, Prue, Sun, Chang-Kai, Cheng, Tao, Zhang, Xiao-Bing
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212847/
https://ncbi.nlm.nih.gov/pubmed/30239926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky804
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