A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding

Recently, Type III-A CRISPR-Cas systems were found to catalyze the synthesis of cyclic oligoadenylates (cOAs), a second messenger that specifically activates Csm6, a Cas accessory RNase and confers antiviral defense in bacteria. To test if III-B CRISPR-Cas systems could mediate a similar CRISPR sign...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Han, Wenyuan, Stella, Stefano, Zhang, Yan, Guo, Tong, Sulek, Karolina, Peng-Lundgren, Li, Montoya, Guillermo, She, Qunxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212834/
https://ncbi.nlm.nih.gov/pubmed/30239876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky844
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