Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs

Fine regulation of the phosphatase and tensin homologue (PTEN) phosphatase dosage is critical for homeostasis and tumour suppression. The 3′-untranslated region (3′-UTR) of Pten mRNA was extensively linked to post-transcriptional regulation by microRNAs (miRNAs). In spite of this critical regulatory...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Thivierge, Caroline, Tseng, Hsin-Wei, Mayya, Vinay K, Lussier, Carine, Gravel, Simon-Pierre, Duchaine, Thomas F
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
RNA and RNA-protein complexes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212768/
https://ncbi.nlm.nih.gov/pubmed/30053103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky666
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