Remarkably Robust Antiviral Immune Response Despite Combined Deficiency in Caspase-8 and RIPK3

Caspase-8 (Casp8)-mediated signaling triggers extrinsic apoptosis while suppressing receptor interacting protein kinase (RIPK)3-dependent necroptosis. Even though Casp8 is dispensable for the development of innate and adaptive immune compartments in mice, the importance of this proapoptotic protease...

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Bibliographic Details
Published in:J Immunol
Main Authors: Feng, Yanjun, Livingston-Rosanoff, Devon, Roback, Linda, Sundararajan, Aarthi, Speck, Samuel H., Mocarski, Edward S., Daley-Bauer, Lisa P.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211196/
https://ncbi.nlm.nih.gov/pubmed/30194111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800110
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