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NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease. Intestinal cholesterol uptake is mediated by Niemann-Pick C1-like 1 (NPC1L1)...
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| 出版年: | J Lipid Res |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6210914/ https://ncbi.nlm.nih.gov/pubmed/30242108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089201 |
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