NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains

Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease. Intestinal cholesterol uptake is mediated by Niemann-Pick C1-like 1 (NPC1L1)...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Nihei, Wataru, Nagafuku, Masakazu, Hayamizu, Hirotaka, Odagiri, Yuta, Tamura, Yumi, Kikuchi, Yui, Veillon, Lucas, Kanoh, Hirotaka, Inamori, Kei-ichiro, Arai, Kenta, Kabayama, Kazuya, Fukase, Koichi, Inokuchi, Jin-ichi
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210914/
https://ncbi.nlm.nih.gov/pubmed/30242108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089201
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