Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti

The ganglioside GM3 synthase (SAT-I), encoded by a single-copy gene, is a primary glycosyltransferase for the synthesis of complex gangliosides. In SAT-I null mice, hearing ability, assessed by brainstem auditory-evoked potentials (BAEP), was impaired at the onset of hearing and had been completely...

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Detalhes bibliográficos
Main Authors: Yoshikawa, Misato, Go, Shinji, Takasaki, Kotaro, Kakazu, Yasuhiro, Ohashi, Mitsuru, Nagafuku, Masakazu, Kabayama, Kazuya, Sekimoto, Junji, Suzuki, Shun-ichi, Takaiwa, Kazutaka, Kimitsuki, Takashi, Matsumoto, Nozomu, Komune, Shizuo, Kamei, Daisuke, Saito, Masaki, Fujiwara, Michihiro, Iwasaki, Katsunori, Inokuchi, Jin-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695060/
https://ncbi.nlm.nih.gov/pubmed/19470479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903279106
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