Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity

Chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. The underlying mechanisms, such as endoplasmic reticulum (ER) stress, oxidative stress and metabolic disorders, have been repo...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Li, Zonghong, Liu, Hongyang, Niu, Zhangjing, Zhong, Wen, Xue, Miaomiao, Wang, Jifeng, Yang, Fuquan, Zhou, Yue, Zhou, Yifa, Xu, Tao, Hou, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210228/
https://ncbi.nlm.nih.gov/pubmed/30082485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000698
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