Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity

Chronic hyperlipidemia causes the dysfunction of pancreatic β-cells, such as apoptosis and impaired insulin secretion, which are aggravated in the presence of hyperglycemia. The underlying mechanisms, such as endoplasmic reticulum (ER) stress, oxidative stress and metabolic disorders, have been repo...

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Dades bibliogràfiques
Publicat a:Mol Cell Proteomics
Autors principals: Li, Zonghong, Liu, Hongyang, Niu, Zhangjing, Zhong, Wen, Xue, Miaomiao, Wang, Jifeng, Yang, Fuquan, Zhou, Yue, Zhou, Yifa, Xu, Tao, Hou, Junjie
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210228/
https://ncbi.nlm.nih.gov/pubmed/30082485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000698
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