Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis Proteins 1/2 (cIAP1/2), critical components of the T...

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Pubblicato in:Oncoimmunology
Autori principali: Xiao, Roy, Allen, Clint T., Tran, Linda, Patel, Priya, Park, So-Jin, Chen, Zhong, Van Waes, Carter, Schmitt, Nicole C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209421/
https://ncbi.nlm.nih.gov/pubmed/30393585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1471440
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