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Vacuolar ATPase Activity Required for ABCA1 Mediated Cholesterol Efflux
OBJECTIVE: We have shown that ABCA1 mediates unfolding of the apoA1 N-terminal helical hairpin during apoA1 lipidation. Others have shown that an acidic pH exposes the hydrophobic surface of apoA1. We postulated that the vacuolar ATPase (V-ATPase) proton pump facilitates apoA1 unfolding and promotes...
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| izdano v: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6209108/ https://ncbi.nlm.nih.gov/pubmed/30354238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311814 |
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