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PI(4,5)P2 is translocated by ABCA1 to the cell surface where it mediates apolipoprotein A1 binding and nascent HDL assembly, and it is carried on HDL
RATIONALE: The molecular mechanism by which ABCA1 mediates cellular binding of apolipoprotein A-I (apoA1) and nascent HDL assembly is not well understood. OBJECTIVE: To determine the cell surface lipid that mediates apoA1 binding to ABCA1 expressing cells and the role it plays in nascent HDL assembl...
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| Publicat a: | Circ Res |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026623/ https://ncbi.nlm.nih.gov/pubmed/27514935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308856 |
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