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Calcium sensing by the STIM1 ER-luminal domain
Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca(2+) levels to maintain cellular Ca(2+) balance and to support Ca(2+) signalling. The prevailing view has been that STIM1 senses reduced ER Ca(2+) through dissociation of bound Ca(2+) from a single EF-hand site, which triggers a dramatic l...
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Veröffentlicht in: | Nat Commun |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Nature Publishing Group UK
2018
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6208404/ https://ncbi.nlm.nih.gov/pubmed/30382093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06816-8 |
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