Calcium sensing by the STIM1 ER-luminal domain

Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca(2+) levels to maintain cellular Ca(2+) balance and to support Ca(2+) signalling. The prevailing view has been that STIM1 senses reduced ER Ca(2+) through dissociation of bound Ca(2+) from a single EF-hand site, which triggers a dramatic l...

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Udgivet i:Nat Commun
Main Authors: Gudlur, Aparna, Zeraik, Ana Eliza, Hirve, Nupura, Rajanikanth, V., Bobkov, Andrey A., Ma, Guolin, Zheng, Sisi, Wang, Youjun, Zhou, Yubin, Komives, Elizabeth A., Hogan, Patrick G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208404/
https://ncbi.nlm.nih.gov/pubmed/30382093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06816-8
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