MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

Despite improvements in overall survival, only a modest percentage of patients survives high-risk medulloblastoma. The devastating side effects of radiation and chemotherapy substantially reduce quality of life for surviving patients. Here, using genomic screens, we identified miR-584-5p as a potent...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Abdelfattah, Nourhan, Rajamanickam, Subapriya, Panneerdoss, Subbarayalu, Timilsina, Santosh, Yadav, Pooja, Onyeagucha, Benjamin C., Garcia, Michael, Vadlamudi, Ratna, Chen, Yidong, Brenner, Andrew, Houghton, Peter, Rao, Manjeet K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208371/
https://ncbi.nlm.nih.gov/pubmed/30382096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06808-8
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