Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation

We show here that the M2 isoform of human pyruvate kinase (M2PYK) is susceptible to nitrosation and oxidation, and that these modifications regulate enzyme activity by preventing the formation of the active tetrameric form. The biotin-switch assay carried out on M1 and M2 isoforms showed that M2PYK...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Mitchell, Alice Rose, Yuan, Meng, Morgan, Hugh P., McNae, Iain W., Blackburn, Elizabeth A., Le Bihan, Thierry, Homem, Rafael A., Yu, Manda, Loake, Gary J., Michels, Paul A., Wear, Martin A., Walkinshaw, Malcolm D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208296/
https://ncbi.nlm.nih.gov/pubmed/30254098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180556
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