Autophagy in Trypanosomatids

Por Brennand, Ana, Rico, Eva, Michels, Paul A. M.
Publicado em 2012

Rewiring and regulation of cross-compartmentalized metabolism in protists

Por Ginger, Michael L., McFadden, Geoffrey I., Michels, Paul A. M.
Publicado em 2010

The evolution of organellar metabolism in unicellular eukaryotes

Por Ginger, Michael L., McFadden, Geoffrey I., Michels, Paul A. M.
Publicado em 2010

Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

Por Gupta, Shreedhara, Igoillo-Esteve, Mariana, Michels, Paul A. M., Cordeiro, Artur T.
Publicado em 2011

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

Por Zíková, Alena, Verner, Zdeněk, Nenarokova, Anna, Michels, Paul A. M., Lukeš, Julius
Publicado no PLoS Pathog (2017)

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

Por Rider, Mark H., Bertrand, Luc, Vertommen, Didier, Michels, Paul A., Rousseau, Guy G., Hue, Louis
Publicado em 2004

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei

Por Brennand, Ana, Rico, Eva, Rigden, Daniel J., Van Der Smissen, Patrick, Courtoy, Pierre J., Michels, Paul A. M.
Publicado no PLoS One (2015)

Compartmentation protects trypanosomes from the dangerous design of glycolysis

Por Bakker, Barbara M., Mensonides, Femke I. C., Teusink, Bas, van Hoek, Pim, Michels, Paul A. M., Westerhoff, Hans V.
Publicado em 2000

Plant-like traits associated with metabolism of Trypanosoma parasites

Por Hannaert, Véronique, Saavedra, Emma, Duffieux, Francis, Szikora, Jean-Pierre, Rigden, Daniel J., Michels, Paul A. M., Opperdoes, Fred R.
Publicado em 2003

Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target

Por Avilán, Luisana, Gualdrón-López, Melisa, Quiñones, Wilfredo, González-González, Limari, Hannaert, Véronique, Michels, Paul A. M., Concepción, Juan-Luis
Publicado em 2011

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

Por Gualdron-López, Melisa, Vapola, Miia H., Miinalainen, Ilkka J., Hiltunen, J. Kalervo, Michels, Paul A. M., Antonenkov, Vasily D.
Publicado em 2012

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

Por Morgan, Hugh P., Zhong, Wenhe, McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado no R Soc Open Sci (2014)

An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase

Por Morgan, Hugh P., McNae, Iain W., Hsin, Kun-Yi, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado em 2010

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

Por Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado no J Mol Biol (2017)

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

Por Haanstra, Jurgen R., van Tuijl, Arjen, Kessler, Peter, Reijnders, Willem, Michels, Paul A. M., Westerhoff, Hans V., Parsons, Marilyn, Bakker, Barbara M.
Publicado em 2008

Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model

Por Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Hannaert, Véronique, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado em 2010

Extra glycosomal localization of Trypanosoma brucei hexokinase 2

Por Joice, April C., Lyda, Todd L., Sayce, Andrew C., Verplaetse, Emilie, Morris, Meredith T., Michels, Paul A. M., Robinson, Derrick R., Morris, James C.
Publicado em 2012

Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei

Por Bakker, Barbara M., Walsh, Michael C., ter Kuile, Benno H., Mensonides, Femke I. C., Michels, Paul A. M., Opperdoes, Fred R., Westerhoff, Hans V.
Publicado em 1999

The Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine Site

Por Morgan, Hugh P., McNae, Iain W., Nowicki, Matthew W., Zhong, Wenhe, Michels, Paul A. M., Auld, Douglas S., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado em 2011

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Por Alloatti, Andrés, Gupta, Shreedhara, Gualdrón-López, Melisa, Igoillo-Esteve, Mariana, Nguewa, Paul A., Deumer, Gladys, Wallemacq, Pierre, Altabe, Silvia G., Michels, Paul A. M., Uttaro, Antonio D.
Publicado em 2010