Autophagy in Trypanosomatids

Por Brennand, Ana, Rico, Eva, Michels, Paul A. M.
Publicado em 2012

Rewiring and regulation of cross-compartmentalized metabolism in protists

Por Ginger, Michael L., McFadden, Geoffrey I., Michels, Paul A. M.
Publicado em 2010

The evolution of organellar metabolism in unicellular eukaryotes

Por Ginger, Michael L., McFadden, Geoffrey I., Michels, Paul A. M.
Publicado em 2010

Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

Por Gupta, Shreedhara, Igoillo-Esteve, Mariana, Michels, Paul A. M., Cordeiro, Artur T.
Publicado em 2011

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex

Por Zíková, Alena, Verner, Zdeněk, Nenarokova, Anna, Michels, Paul A. M., Lukeš, Julius
Publicado no PLoS Pathog (2017)

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

Por Rider, Mark H., Bertrand, Luc, Vertommen, Didier, Michels, Paul A., Rousseau, Guy G., Hue, Louis
Publicado em 2004

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches

Por Fernandes, Peter M., Kinkead, James, McNae, Iain, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado no Biochem J (2020)

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei

Por Brennand, Ana, Rico, Eva, Rigden, Daniel J., Van Der Smissen, Patrick, Courtoy, Pierre J., Michels, Paul A. M.
Publicado no PLoS One (2015)

The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

Por Marchese, Letícia, Nascimento, Janaina de Freitas, Damasceno, Flávia Silva, Bringaud, Frédéric, Michels, Paul A. M., Silber, Ariel Mariano
Publicado no Pathogens (2018)

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

Por Fernandes, Peter M., Kinkead, James, McNae, Iain W., Bringaud, Frédéric, Michels, Paul A.M., Walkinshaw, Malcolm D.
Publicado no Biochem J (2019)

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

Por Quiñones, Wilfredo, Acosta, Héctor, Gonçalves, Camila Silva, Motta, Maria Cristina M., Gualdrón-López, Melisa, Michels, Paul A. M.
Publicado no Front Cell Infect Microbiol (2020)

Compartmentation protects trypanosomes from the dangerous design of glycolysis

Por Bakker, Barbara M., Mensonides, Femke I. C., Teusink, Bas, van Hoek, Pim, Michels, Paul A. M., Westerhoff, Hans V.
Publicado em 2000

Plant-like traits associated with metabolism of Trypanosoma parasites

Por Hannaert, Véronique, Saavedra, Emma, Duffieux, Francis, Szikora, Jean-Pierre, Rigden, Daniel J., Michels, Paul A. M., Opperdoes, Fred R.
Publicado em 2003

Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target

Por Avilán, Luisana, Gualdrón-López, Melisa, Quiñones, Wilfredo, González-González, Limari, Hannaert, Véronique, Michels, Paul A. M., Concepción, Juan-Luis
Publicado em 2011

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

Por Gualdron-López, Melisa, Vapola, Miia H., Miinalainen, Ilkka J., Hiltunen, J. Kalervo, Michels, Paul A. M., Antonenkov, Vasily D.
Publicado em 2012

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

Por Morgan, Hugh P., Zhong, Wenhe, McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado no R Soc Open Sci (2014)

An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase

Por Morgan, Hugh P., McNae, Iain W., Hsin, Kun-Yi, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado em 2010

Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition

Por Yuan, Meng, Vásquez-Valdivieso, Montserrat G., McNae, Iain W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Publicado no J Mol Biol (2017)

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

Por Rojas-Pirela, Maura, Andrade-Alviárez, Diego, Rojas, Verónica, Kemmerling, Ulrike, Cáceres, Ana J., Michels, Paul A., Concepción, Juan Luis, Quiñones, Wilfredo
Publicado no Open Biol (2020)

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

Por Haanstra, Jurgen R., van Tuijl, Arjen, Kessler, Peter, Reijnders, Willem, Michels, Paul A. M., Westerhoff, Hans V., Parsons, Marilyn, Bakker, Barbara M.
Publicado em 2008