Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg (null)) mice, severe graft versus host...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Yaguchi, Tomonori, Kobayashi, Asuka, Inozume, Takashi, Morii, Kenji, Nagumo, Haruna, Nishio, Hiroshi, Iwata, Takashi, Ka, Yuyo, Katano, Ikumi, Ito, Ryoji, Ito, Mamoru, Kawakami, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207709/
https://ncbi.nlm.nih.gov/pubmed/29151581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2017.106
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