Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg (null)) mice, severe graft versus host...

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Bibliografiska uppgifter
I publikationen:Cell Mol Immunol
Huvudupphovsmän: Yaguchi, Tomonori, Kobayashi, Asuka, Inozume, Takashi, Morii, Kenji, Nagumo, Haruna, Nishio, Hiroshi, Iwata, Takashi, Ka, Yuyo, Katano, Ikumi, Ito, Ryoji, Ito, Mamoru, Kawakami, Yutaka
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207709/
https://ncbi.nlm.nih.gov/pubmed/29151581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2017.106
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