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ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association

MITA is a central adaptor in innate immune responses to DNA viruses. The mechanisms responsible for recruitment of downstream kinase TBK1 and the transcription factor IRF3 to MITA remains enigmatic. Here we identified ZDHHC11, a member of DHHC palmitoyl transferase family, as a positive regulator of...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Liu, Ying, Zhou, Qian, Zhong, Li, Lin, Heng, Hu, Ming-Ming, Zhou, Yan, Shu, Hong-Bing, Li, Shu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207569/
https://ncbi.nlm.nih.gov/pubmed/29429998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2017.146
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