SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response. Here we found that SNX8 is a componen...

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Foilsithe in:PLoS Pathog
Main Authors: Wei, Jin, Lian, Huan, Guo, Wei, Chen, Yun-Da, Zhang, Xia-Nan, Zang, Ru, Zhong, Li, Yang, Qing, Hu, Ming-Ming, Luo, Wei-Wei, Shu, Hong-Bing, Li, Shu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188873/
https://ncbi.nlm.nih.gov/pubmed/30321235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007336
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