SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response. Here we found that SNX8 is a componen...

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Vydáno v:PLoS Pathog
Hlavní autoři: Wei, Jin, Lian, Huan, Guo, Wei, Chen, Yun-Da, Zhang, Xia-Nan, Zang, Ru, Zhong, Li, Yang, Qing, Hu, Ming-Ming, Luo, Wei-Wei, Shu, Hong-Bing, Li, Shu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188873/
https://ncbi.nlm.nih.gov/pubmed/30321235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007336
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