SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

MITA (also called STING) is a central adaptor protein in innate immune response to cytosolic DNA. Cellular trafficking of MITA from the ER to perinuclear microsomes after DNA virus infection is critical for MITA activation and onset of innate antiviral response. Here we found that SNX8 is a componen...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Wei, Jin, Lian, Huan, Guo, Wei, Chen, Yun-Da, Zhang, Xia-Nan, Zang, Ru, Zhong, Li, Yang, Qing, Hu, Ming-Ming, Luo, Wei-Wei, Shu, Hong-Bing, Li, Shu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188873/
https://ncbi.nlm.nih.gov/pubmed/30321235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007336
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