Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys

Though immune correlates for protection are still under investigation, potent cytotoxic T lymphocyte responses are desirable for an ideal HIV-1 vaccine. PD-1 blockade enhances SIV-specific CD8+ T cells. However, little information has been reported about how it affects the immunogenicity and protect...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Pan, Enxiang, Feng, Fengling, Li, Pingchao, Yang, Qing, Ma, Xiuchang, Wu, Chunxiu, Zhao, Jin, Yan, Hongbin, Chen, Rulei, Chen, Ling, Sun, Caijun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206945/
https://ncbi.nlm.nih.gov/pubmed/30405615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02415
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