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Protective Efficacy of Adenovirus/Protein Vaccines Against SIV Challenges in Rhesus Monkeys

Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against stringent virus challenges in rhesus monkeys. In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by boosting with a purified e...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Barouch, Dan H., Alter, Galit, Broge, Thomas, Linde, Caitlyn, Ackerman, Margaret E., Brown, Eric P., Borducchi, Erica N., Smith, Kaitlin M., Nkolola, Joseph P., Liu, Jinyan, Shields, Jennifer, Parenteau, Lily, Whitney, James B., Abbink, Peter, Ng’ang’a, David M., Seaman, Michael S., Lavine, Christy L., Perry, James R., Li, Wenjun, Colantonio, Arnaud D., Lewis, Mark G., Chen, Bing, Wenschuh, Holger, Reimer, Ulf, Piatak, Michael, Lifson, Jeffrey D., Handley, Scott A., Virgin, Herbert W., Koutsoukos, Marguerite, Lorin, Clarisse, Voss, Gerald, Weijtens, Mo, Pau, Maria G., Schuitemaker, Hanneke
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653134/
https://ncbi.nlm.nih.gov/pubmed/26138104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab3886
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