The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K/Akt and p53 signaling pathways

Cisplatin, a potent anticancer drug, is usually causing nephrotoxicity; limiting its therapeutic application and efficiency. Maltol may be used to prevent such toxic effect. The aim of this study was to investigate the underlying protective mechanisms of maltol on nephrotoxicity by cisplatin using a...

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Vydáno v:Sci Rep
Hlavní autoři: Mi, Xiao-jie, Hou, Jin-gang, Wang, Zi, Han, Ye, Ren, Shen, Hu, Jun-nan, Chen, Chen, Li, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206039/
https://ncbi.nlm.nih.gov/pubmed/30374107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34156-6
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