The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells

Apigenin is a member of the flavone subclass of flavonoids present in fruits and vegetables. Apigenin has long been considered to have various biological activities, such as antioxidant, anti-inflammatory, and antitumorigenic properties, in various cell types. Cisplatin was known to exhibit cytotoxi...

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Vydáno v:Evid Based Complement Alternat Med
Hlavní autoři: Ju, Sung Min, Kang, Jun Gue, Bae, Jun Sang, Pae, Hyun Ock, Lyu, Yeoung Su, Jeon, Byung Hun
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454761/
https://ncbi.nlm.nih.gov/pubmed/26089934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/186436
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