Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Although cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS) exerted protective effects in various an...

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Bibliographic Details
Published in:Nutrients
Main Authors: Zhang, Weizhe, Hou, Jingang, Yan, Xiaotong, Leng, Jing, Li, Rongyan, Zhang, Jing, Xing, Jingjing, Chen, Chen, Wang, Zi, Li, Wei
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6164643/
https://ncbi.nlm.nih.gov/pubmed/30235825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu10091328
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