A comprehensive overview of FCGR3A gene variability by full-length gene sequencing including the identification of V158F polymorphism

The FCGR3A gene encodes for the receptor important for antibody-dependent natural killer cell-mediated cytotoxicity. FCGR3A gene polymorphisms could affect the success of monoclonal antibody therapy. Although polymorphisms, such as the FcγRIIIA-V158F and -48L/R/H, have been studied extensively, an o...

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Udgivet i:Sci Rep
Main Authors: Mahaweni, Niken M., Olieslagers, Timo I., Rivas, Ivan Olivares, Molenbroeck, Stefan J. J., Groeneweg, Mathijs, Bos, Gerard M. J., Tilanus, Marcel G. J., Voorter, Christina E. M., Wieten, Lotte
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206037/
https://ncbi.nlm.nih.gov/pubmed/30374078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34258-1
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