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Daratumumab augments alloreactive natural killer cell cytotoxicity towards CD38+ multiple myeloma cell lines in a biochemical context mimicking tumour microenvironment conditions

Natural killer (NK) cell-based immunotherapy is a promising novel approach to treat cancer. However, NK cell function has been shown to be potentially diminished by factors common in the tumor microenvironment (TME). In this study, we assessed the synergistic potential of antibody-dependent cell-med...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Mahaweni, Niken M., Bos, Gerard M. J., Mitsiades, Constantine S., Tilanus, Marcel G. J., Wieten, Lotte
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951903/
https://ncbi.nlm.nih.gov/pubmed/29500635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2140-1
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