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Noncanonical autophagy at ER exit sites regulates procollagen turnover

Type I collagen is the main component of bone matrix and other connective tissues. Rerouting of its procollagen precursor to a degradative pathway is crucial for osteoblast survival in pathologies involving excessive intracellular buildup of procollagen that is improperly folded and/or trafficked. W...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Omari, Shakib, Makareeva, Elena, Roberts-Pilgrim, Anna, Mirigian, Lynn, Jarnik, Michal, Ott, Carolyn, Lippincott-Schwartz, Jennifer, Leikin, Sergey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205486/
https://ncbi.nlm.nih.gov/pubmed/30287488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814552115
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