Osteoblast malfunction caused by cell stress response to procollagen misfolding in α2(I)-G610C mouse model of osteogenesis imperfecta

Glycine (Gly) substitutions in collagen Gly-X-Y repeats disrupt folding of type I procollagen triple helix and cause severe bone fragility and malformations (osteogenesis imperfecta, aka OI). However, these mutations do not elicit the expected Endoplasmic Reticulum (ER) stress response, in contrast...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Bone Miner Res
Autores principales: Mirigian, Lynn S., Makareeva, Elena, Mertz, Edward L., Omari, Shakib, Roberts-Pilgrim, Anna M., Oestreich, Arin K., Phillips, Charlotte L., Leikin, Sergey
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061462/
https://ncbi.nlm.nih.gov/pubmed/26925839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2824
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares