iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors, including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes cancer progression and requires Notch cleavage by ADAM (a disintegrin and metalloprotease) proteases. We hypothesized th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Ronghua, Li, Yawen, Tsung, Allan, Huang, Hai, Du, Qiang, Yang, Muqing, Deng, Meihong, Xiong, Si, Wang, Xiju, Zhang, Liyong, Geller, David A., Cheng, Bin, Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205478/
https://ncbi.nlm.nih.gov/pubmed/30297396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722100115
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