iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors, including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes cancer progression and requires Notch cleavage by ADAM (a disintegrin and metalloprotease) proteases. We hypothesized th...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wang, Ronghua, Li, Yawen, Tsung, Allan, Huang, Hai, Du, Qiang, Yang, Muqing, Deng, Meihong, Xiong, Si, Wang, Xiju, Zhang, Liyong, Geller, David A., Cheng, Bin, Billiar, Timothy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205478/
https://ncbi.nlm.nih.gov/pubmed/30297396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722100115
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