iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

The inducible nitric oxide synthase (iNOS) is associated with more aggressive solid tumors, including hepatocellular carcinoma (HCC). Notch signaling in cancer stem cells promotes cancer progression and requires Notch cleavage by ADAM (a disintegrin and metalloprotease) proteases. We hypothesized th...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wang, Ronghua, Li, Yawen, Tsung, Allan, Huang, Hai, Du, Qiang, Yang, Muqing, Deng, Meihong, Xiong, Si, Wang, Xiju, Zhang, Liyong, Geller, David A., Cheng, Bin, Billiar, Timothy R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205478/
https://ncbi.nlm.nih.gov/pubmed/30297396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722100115
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