Cancer-associated fibroblasts promote stem cell-like properties of hepatocellular carcinoma cells through IL-6/STAT3/Notch signaling

In this study, we investigated the role of cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC) progression. We showed that CAFs secrete high levels of IL-6, which promoted stem cell-like properties in HCC cells by activating Notch signaling through STAT3 Tyr705 phosphorylation. Th...

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Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Xiong, Si, Wang, Ronghua, Chen, Qian, Luo, Jing, Wang, Jinlin, Zhao, Zhenxiong, Li, Yawen, Wang, Yun, Wang, Xiju, Cheng, Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2018
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835697/
https://ncbi.nlm.nih.gov/pubmed/29511600
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