Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

Arteriolar endothelial cell–expressed (EC-expressed) α-globin binds endothelial NOS (eNOS) and degrades its enzymatic product, NO, via dioxygenation, thereby lessening the vasodilatory effects of NO on nearby vascular smooth muscle. Although this reaction potentially affects vascular physiology, the...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Lechauve, Christophe, Butcher, Joshua T., Freiwan, Abdullah, Biwer, Lauren A., Keith, Julia M., Good, Miranda E., Ackerman, Hans, Tillman, Heather S., Kiger, Laurent, Isakson, Brant E., Weiss, Mitchell J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205378/
https://ncbi.nlm.nih.gov/pubmed/30295646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99933
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