Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

Arteriolar endothelial cell–expressed (EC-expressed) α-globin binds endothelial NOS (eNOS) and degrades its enzymatic product, NO, via dioxygenation, thereby lessening the vasodilatory effects of NO on nearby vascular smooth muscle. Although this reaction potentially affects vascular physiology, the...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lechauve, Christophe, Butcher, Joshua T., Freiwan, Abdullah, Biwer, Lauren A., Keith, Julia M., Good, Miranda E., Ackerman, Hans, Tillman, Heather S., Kiger, Laurent, Isakson, Brant E., Weiss, Mitchell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205378/
https://ncbi.nlm.nih.gov/pubmed/30295646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99933
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