Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-PropanolMediated Reductive Coupling

Cyclometalated π-allyliridium C,O-benzoates modified by (S)-SEGPHOS or (S)-Cl,OMe-BIPHEP catalyze enantioselective 2propanol-mediated reductive couplings of diverse non-metallic allyl pronucleophiles with the acetylenic aldehyde TIPSC≡CCHO. Absolute stereochemistry of the resulting secondary homoall...

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Bibliographic Details
Published in:Org Lett
Main Authors: Brito, Gilmar A., Della-Felice, Franco, Luo, Guoshun, Burns, Alexander S., Pilli, Ronaldo A., Rychnovsky, Scott D., Krische, Michael J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205292/
https://ncbi.nlm.nih.gov/pubmed/29938513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b01776
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