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Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer
BACKGROUND: R132H mutation of isocitrate dehydrogenase 1 (IDH1) are found in ~75% of low-grade gliomas and secondary glioblastomas as well as in several other types of cancer. More chemotypes of inhibitors of IDH1(R132H) are therefore needed. OBJECTIVE: To develop a new class of IDH1(R132H) inhibito...
Gorde:
| Argitaratua izan da: | Med Chem |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205205/ https://ncbi.nlm.nih.gov/pubmed/29792149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1573406414666180524093659 |
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