Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. A number of the benzylpyridinium derivatives exhibited potent activities with inhibitory concentrat...

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Veröffentlicht in:Beilstein J Org Chem
Hauptverfasser: Khunnawutmanotham, Nisachon, Laongthipparos, Cherdchai, Saparpakorn, Patchreenart, Chimnoi, Nitirat, Techasakul, Supanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204823/
https://ncbi.nlm.nih.gov/pubmed/30410615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.231
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