Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.

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Detalhes bibliográficos
Main Authors: Khunnawutmanotham, Nisachon, Chimnoi, Nitirat, Thitithanyanont, Arunee, Saparpakorn, Patchreenart, Choowongkomon, Kiattawee, Pungpo, Pornpan, Hannongbua, Supa, Techasakul, Supanna
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2009
Assuntos:
Full Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748688/
https://ncbi.nlm.nih.gov/pubmed/19777131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.5.36
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