Novel 2-Chloro-8-arylthiomethyldipyridodiazepinone Derivatives with Activity against HIV-1 Reverse Transcriptase †

Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and...

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Publicado no:Molecules
Main Authors: Khunnawutmanotham, Nisachon, Chimnoi, Nitirat, Saparpakorn, Patchareenart, Pungpo, Pornpan, Louisirirotchanakul, Suda, Hannongbua, Supa, Techasakul, Supanna
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149348/
https://ncbi.nlm.nih.gov/pubmed/17846572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/12020218
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