Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase

A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. A number of the benzylpyridinium derivatives exhibited potent activities with inhibitory concentrat...

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Detaylı Bibliyografya
Yayımlandı:Beilstein J Org Chem
Asıl Yazarlar: Khunnawutmanotham, Nisachon, Laongthipparos, Cherdchai, Saparpakorn, Patchreenart, Chimnoi, Nitirat, Techasakul, Supanna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Beilstein-Institut 2018
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Full Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204823/
https://ncbi.nlm.nih.gov/pubmed/30410615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.231
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