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Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells

Despite the major negative impact uterine fibroids (UFs) have on female reproductive health, little is known about early events that initiate development of these tumors. Somatic fibroid-causing mutations in mediator complex subunit 12 (MED12), the most frequent genetic alterations in UFs (up to 85%...

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Bibliografische gegevens
Gepubliceerd in:Biol Reprod
Hoofdauteurs: Prusinski Fernung, Lauren E, Yang, Qiwei, Sakamuro, Daitoku, Kumari, Alpana, Mas, Aymara, Al-Hendy, Ayman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203880/
https://ncbi.nlm.nih.gov/pubmed/29688260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioy097
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