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Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells

Despite the major negative impact uterine fibroids (UFs) have on female reproductive health, little is known about early events that initiate development of these tumors. Somatic fibroid-causing mutations in mediator complex subunit 12 (MED12), the most frequent genetic alterations in UFs (up to 85%...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Prusinski Fernung, Lauren E, Yang, Qiwei, Sakamuro, Daitoku, Kumari, Alpana, Mas, Aymara, Al-Hendy, Ayman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203880/
https://ncbi.nlm.nih.gov/pubmed/29688260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biolre/ioy097
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