Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion

Dynamic communication between integrin-containing complexes (focal adhesions, FAs) and actin filaments is critical for regulating cell adhesion. Pseudokinase ILK plays a key role in this process but the underlying mechanism remains highly elusive. Here we show that by recruiting FA adaptors PINCH an...

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Udgivet i:Nat Commun
Main Authors: Vaynberg, Julia, Fukuda, Koichi, Lu, Fan, Bialkowska, Katarzyna, Chen, Yinghua, Plow, Edward F., Qin, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203859/
https://ncbi.nlm.nih.gov/pubmed/30367047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06906-7
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