T cell-dependent affinity maturation and innate immune pathways differentially drive autoreactive B cell responses in rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is characterized by the activation of B cells that produce anti-citrullinated protein antibodies (ACPA) and rheumatoid factors (RF), but the mechanisms by which tolerance is broken in these B cells remain incompletely understood. Here we investigate whether ACPA...

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Udgivet i:Arthritis Rheumatol
Main Authors: Lu, Daniel R., McDavid, Andrew N., Kongpachith, Sarah, Lingampalli, Nithya, Glanville, Jacob, Ju, Chia-Hsin, Gottardo, Raphael, Robinson, William H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203609/
https://ncbi.nlm.nih.gov/pubmed/29855173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40578
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